Istrus lies in the southern Drakefire Peninsula and serves as the traditional southern reference point for the Protectorate of Arkrist. Arkrist claims authority over the settlements of the peninsula as far south as Istrus, placing it at the outer edge of the region administered through the city’s government.

In wider accounts of Arkrist, Istrus is most often significant as a marker of the city’s political reach rather than as an extension of Arkrist itself. The Protectorate includes communities with their own local concerns even where the Polemarch claims responsibility for their administration and defense.